Bee venom chewable tablets is completely natural and unique product of New Zealand
Specially formulated chewable tablets with pure New Zealand bee venom and Glucosamine Sulphate & UMF Manuka honey to assist with joints mobility in dogs and cats.
It is good for pets suffering of joints and muscles diseases, functional disorders of muscles and chords. BV honey provides a very strong pain relief and anti-inflammatory effect. Taken regularly, over the time it helps minimize joint discomfort and helps maintain and restore joint mobility.
The key unique healing ingredient of ApiVENZ Relief tablets is certified natural dried New Zealand bee venom VENZTM. Each 500 mg of tablet contains to the following active ingredients:
HOW TO TAKE "ApiVENZTM RELIEF TABLETS FOR PETS"
The Bee Venom concentration in one tablet is 50 microgram, which equals to quarter a bee sting. We would recommend to start: for small dogs and cats- ˝ tablets every day; for large dogs 1 tablets every day. If no allergic reaction occurs, increase the dosage gradually: for small dogs and cats - 1 tablet every day, for large dog and horses - 2 tablets every day. After two weeks make break during a few days and start again.
If your pets suffer allergic reaction to bee sting, please consult your pet care before use this product.
General information about Bee Venom
Honeybee venom is a well-known pharmacologically active product of the hive. It is a product of the secretion activity of a special gland in the body of working honeybees. Freshly collected bee venom is a transparent, light-yellow liquid with a bitter burning taste and a strong smell.
Bee venom is a unique multi-component complex, which contains about 18 biologically active compounds, some of which are practically impossible to get synthesized by chemical methods (Fig.1). Nowadays the majority of biologically active compounds are well studied, their useful properties are discovered (Krilov, 1995; Schmidt, 1996)
The most powerful bee venom ingredients are:
1. Melittin - ( 40-50 % ) - the most potent anti-inflammatory peptide
2. Peptide 401 - 2 % - strong anti-inflammatory peptide.
3. Apamin - Apamin works like melittin to produce cortisone (Vick and Shipman, 1972), and inhibits the complement system, C3, which is involved in inflammation (Gencheva et al., 1986).
4. Cardio peptides - anti-arrhythmic agent.
5. Dopamine - a neurotransmitter that increases motor activity.
6. Adolapin - Has very strong analgesic effect
How does bee venom work?
Bee venom peptides have systemic action: anti-inflammatory, anti-fungal, anti-bacterial, anti-pyretic, stimulating vascular permeability.
There are different mechanisms of bee venom action in the body - indirectly through hormone system and directly on cardiovascular system.
1. Indirectly, through hormone system.
The healing effect of bee venom is caused by its stimulating the function of adrenal gland indirectly through hypophysis. Due to this stimulation process more adrenal hormones such as cortisone and hydrocortisone are generated in blood. These hormones provide healing effect, increasing resistibility of the body against various unfavourable factors. But bee venom healing action not only connected with stimulation of adrenal gland
2. Directly, through cardiovascular system
Russian scientists have discovered that bee venom contributes to capillary vessels and small artery distention, increasing the blood surge to the organs and promoting metabolism improvement. Since bee venom increases the content of haemoglobin and leukocytes in blood and decreases blood thickness and coagulability, it can be very helpful for people having susceptibility to trombophlebitis. Bee venom promotes decrease of cholesterol content in blood, provides tonic effect for a heart muscle, and decreases blood pressure.
It improves patients overall state of health, appetite and sleep, increases vitality. It is good for body strengthening and pain relief.( Krylov,1995 )
Bee venom honey as a food supplement for pets.
For the first time in New Zealand a new health product with bee venom for oral use has been developed and produced. This is Manuka Honey with bee venom and chewable tablets with bee venom for pets. These products provide an alternative method of achieving the same health benefit of bee sting therapy, but without the pain.
Production technology has been developed and patented by ApiHealth (NZ patent #333790).
Dr. Nikolai Nikolaev suggested using dry bee venom powder VENZTM for making honey based products and developed the technology of mixing both liquid and dry honey with dry bee venom. The safe and beneficial health dosage of bee venom in the products was scientifically substantiated, as outlined below. This technology was recognized as innovative (NZ patent #333790). The main advantage of this technology is the possibility of standardization of bee venom dosage in a final product. Another advantage is preservation of biologically active components of honey and bee venom and their healing properties during a long period of time.
sulphate is a synthesised salt of glucosamine. It is a major component
of soft tissues such as cartilage, ligament, tendon, skin etc. Glucosamine
is produced in the body from glucose and an amino acid, glutamine.
It stimulates the manufacture of the soft tissue, as well as promoting
the incorporation of sulfur into the tissue, and is therefore responsible
for both the manufacture and proper function of joints and tissue
such as ligaments, tendons and cartilage.
Glucosamine sulphate has been reported to have the potential to slow the degradation of cartilage and can also help the body repair eroded and damaged cartilage. Glucosamine not only stimulates the production of cartilage but it can also improve joint function and help reduce the pain of those suffering from osteoarthritis.
such as joint tenderness, pain on standing, pain on walking, joint
swelling and spontaneous pain can be reduced.
Our Glucosamine Sulphate, a dietary supplement, packed in premises licensed and audited by the New Zealand Ministry of Health and the New Zealand Ministry of Agriculture and Forestry. All of our Glucosamine Sulphate is 100% pure and contains no additives, fillers or preservatives.
Manuka honey is a superior treatment for wounds and infections. Manuka honey is gathered in New Zealand from Manuka bush , Leptospermum scoparium, which grows uncultivated throughout the country. Research by Dr. Peter Molan MBE of Waikato University has shown that Manuka honey has very potent anti-bacterial activity and very effective in destroying many stains of bacteria.
Basic or clinical research performed previously on our products
During the last seven decades, over 1700 scientific publications on the composition and various effects of bee venom therapy in animals and humans have been published. Overwhelming amount of the publications come from Eastern Europe and Asia. The employment of various animal models is a popular method of conducting such research. In models (normally using laboratory rats) various inflammatory agents are injected into a joint to cause inflammation, a condition referred to as adjuvant induced arthritis ( Schmidt & Buchman , 1992 )
Research conducted by Y. Chang & M. Bliven in 1979 determined that whole bee venom not only reduced inflammation, but also prevented the development of arthritis in rats. A single dose of bee venom was administered subcutaneously the day before or the day of the introduction of the adjuvant. The bee venom was found to effectively suppress the development of arthritis.
O. Lorenzetti, B. Fortenberry and E. Busby achieved similar finding in their research in 1972. In this research bee venom was administered to rats three times per week beginning two weeks before or one week after introduction of the adjuvant. Swelling, lesions and inflammation were noticeably decreased in rats treated with bee venom.
Research conducted by J. Eiseman, J. VonBredow, and A. Alvares in 1981 demonstrated, that bee venom (when administered daily for twenty-four days) has the ability to suppress but not abolish the inflammation of rat paw arthritis.
A study with whole bee venom on arthritis dogs, suffering from hip dysplasia (Vick and Brooks, 1972) and rats (Dunn, 1984) showed that cage activity of the arthritis dogs increased by as much as 70 % following the therapy. The blood monitoring indicated that melittin and apamine stimulated the production of the plasma cortisol. Together with various other arguments, this suggests that many of the curative effects of bee venom may work through stimulation of the body’s enzyme and immune system, in a way similar to the common drug cortisone. Cortisone has been used in the treatment of many ailments, but it is also known to have strong, undesirable side effects. Melittin also appears to have toxic side effects, as do some of the other individual compounds in venom. When whole venom is applied however, no side effects have been shown, other than in allergic patients (Broadman, 1962 and Weeks, 1992 personal communication).
Such studies need to be viewed with caution however, as it is not always easy to extrapolate animal model results to human situations. Many anecdotal reports exist already about the benefit of using BVT for people suffering arthritis, a disease that affects many people and causes considerable disability and health care expenditures.
Recently, after long efforts by the American Apitherapy Society and its members, some interest has been shown by national institutions in several Western European countries and the USA for clinical and large scale tests of bee venom therapy.
At the 44th Annual Scientific Conference of the Australian Rheumatology Association (2001) using bee venom honey against joint and muscle problems was mentioned along with the traditional medicine remedies.
"Two Australian therapies curried out a double blind crossover trial of bee venom in Manuka honey versus Manuka honey in arthritis. This carefully performed study involved 94 patients (58 with osteoarthritis and 36 with rheumatoid arthritis). The bee venom and honey or honey alone was taken over 4 weeks with 6-week washout period and a further 4 - weeks crossover treatment. Seventy-eight patients completed the study. There was significant improvement in pain in osteoarthritis but not in rheumatoid arthritis and in mobility in both osteoarthritis and rheumatoid arthritis. In summary, bee venom in Manuka honey seemed to be effective in reducing pain and increasing mobility in arthritis, but the magnitude of the effect was not so effective." (From the Report from the 44th Annual Scientific conference of the Australian Rheumatology Association).
A good summary of the scientific studies. with further references can be found in Banks and Shipolini (1986) and Schmidt (1992). Summaries of some of the major specific effects of the various venom compounds that are shorter and more easily understood, can be Lund in Mraz (1983), Dotimas and Hider (1987), Crane (1990) and Schmidt and Buchniaflfl (1992).
Bee Venom Bibliography
Menlo Park, Calif.: Addison-Wesley.
Agents Actions 9, pp.205-211.
in American Bee Journal 113, pp.352-355.
in J. Econ. Entomol. 40, pp.469-472.
in Amer. J. Med. Sci. 201, pp.796-801.
in Ann. Intern. Med. 11, pp.1077-1083.
in New Zealand Medical Journal, pp.281-283.
in Toxicon 10, pp.581-586.
Canadian Distributor Mond Trading Co. - Toronto,
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